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MD analysis The mean binding free energies from all MD simulations are 12.7041 0.3243 kcal/mol for CME_a, 11.1474 0.8642 kcal/mol for CME_b, 15.4422 1.5895 kcal/mol for CME_c, and 39.3216 0.7125 kcal/mol for CME_d

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