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Processing of proglucagon to GLP-1 in pancreatic -cells: is this a paracrine mechanism enabling GLP-1 to act on -cells

Farr OM, Sofopoulos M, Tsoukas MA, et al

Dose increases beyond 12mg dont occur in current protocols because 12mg represents maximum studied dose, not because higher doses are needed

It is also different from approved medicines supplied for diagnosed conditions

: 2016 UpToDate Summary adjunct therapy to reduce Hb A1c levels in patients with Type 2 diabetes who are inadequately controlled by other hypoglycemic agents

You can maintain a healthy lifestyle, exercise regularly, and watch your diet, yet still struggle with stubborn submental fat or skin laxity that simply won't respond to traditional weight loss methods