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Boosting intracellular NAD+ levels with nicotinamide riboside (NR) prevented senescence and SASP by promoting mitophagy in a PINK1dependent manner

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Current research has delineated several pivotal axes in ferroptosis regulation: iron homeostasis modulation (e.g., NCOA4/TfR pathway), antioxidant defense (System xc /GPX4 axis), and lipid remodeling (ACSL4/ALOX15 pathway)