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Hildebrandt MA , Komaki R, Chang JY, Liao Z, Stewart DJ, Ye Y, Gu J, Spitz MR, Wu X

For people interested in non-injectable options, sublingual semaglutide represents an emerging alternative, though the evidence base is less established than for injectable forms

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## Understanding Why the 48-Hour Rule Exists Semaglutide has a half-life of approximately **7 days** meaning that one week after your [injection guide](/guides/how-to-inject-semaglutide-step-by-step-guide)ion, roughly half the medication is still circulating in your body

Advise patients on the symptoms of hypersensitivity reactions and instruct them to stop taking RYBELSUS or OZEMPIC tablets and seek medical advice promptly if such symptoms occur [see Warnings and Precautions (5.7)]

Wang R-Q et al