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By using patch-clamp, we first showed that derived neurons exhibited voltage-gated sodium-channel mediated action potentials and received synaptic inputs (Fig

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, 104 , 29-41, doi: Hiyama, N., Ando, T., Maemura, K., Sakatani, T., Amano, Y., Watanabe, K., Kage, H., Yatomi, Y., Nagase, T., Nakajima, J., and Takai, D

Particularly, it was recently demonstrated in a large multiethnic study that the GPx3 loci was strongly associated with a similar motor neuron disease, ALS, perhaps identifying a risk locus for neuronal disease susceptibility 20,38