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372 Allopurinol, categorized as a purine-like XO inhibitor, and febuxostat and topiroxostat, classified as non-purine XO inhibitors, constitute the primary pharmacological approach for ULT

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After consideration of public comments we received, we are finalizing our proposal to use scaled OPPS relative weights to establish ASC relative payment weights and to use the ratio of CY 2025 to CY 2026 total payments (the weight scalar) to scale the ASC relative payment weights for CY 2026

Inside the mitochondrial matrix, the acyl group is transferred back to CoA by carnitine palmitoyltransferase II (CPT-II), allowing the fatty acid to enter the -oxidation cycle