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Vascular endothelial growth factor (VEGF) is a key protein that stimulates angiogenesis

PMID: 7592866

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They stimulate the synthesis of collagen and glycosaminoglycans, which improves skin firmness and elasticity

STEP 2 showed 1.0 mg kept about 73% of the 2.4 mg weight effect in type 2 diabetes with obesity. That is the clearest lower-dose weight evidence semaglutide has, though it is not the same as saying 1.0 mg equals 2.4 mg for everyone