But reaching a sensible conclusion seems so much rarer in the face of a powerful trend that brings self-optimization to a toxic extreme
Supplementary Materials: The following supporting information can be downloaded: Table S1: Risk of Bias Table
Indications: Overactive bladder Common symptoms include urgency, urinary incontinence, and increased urinary frequency Side Effects: increased blood pressure / hypertension urinary tract infections nasopharyngitis constipation Pharmacokinetics: taken orally by tablet, 25 mg once daily metabolized via multiple pathways involving dealkylation, oxidation, glucuronidation, and hydrolysis 6-12% is eliminated unchanged by the kidney, involving glomerular filtration and active secretion that is dose-dependent Drug Interactions: mirabegron is a moderate inhibitor of CYP2D6 Notes: the estimated Walmart cost for Mybetriq oral 50mg tablets is ~$440 for a supply of 30 tablets (GoodRx.com
Longitudinal studies are needed to track changes in microbiota over time and to correlate these changes with treatment response and disease progression
Normal saline is sterile, readily available, and used in countless clinical applications
Oral supplements offer convenience, availability, gradual absorption, and cost-effectiveness compared to IV administration
