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Moreover, the follow-up period was relatively short, preventing evaluation of recurrence rates or long-term prophylactic benefits

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aeruginosa has been shown to upregulate mucin secretion through the activation of the EGFR pathway by inducing intracellular reactive oxygen species, triggering cytokine production (e.g., IL-1, IL-1, IL-6, IL-8, TNF-), and generating EGFR ligands such as TGF- in epithelial cells (Shao et al., 2003

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