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Structures of full-length class B receptors were determined in complex with their orthosteric agonist peptides, however, little is known about their extracellular domain (ECD) conformations in the absence of orthosteric ligands, which has limited our understanding of their activation mechanism

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We therefore hypothesised that SFN should have anti-parasitic activity, and determined an IC 50 of 11.8 0.4 M for SFN in a standard growth inhibition assay in Pf3D7 wildtype parasites (Supp Fig 4A)

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