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Elevated iron levels in the gray matter of patients with AD have been documented (1), along with dysregulated iron homeostasis and lipid peroxidation, hallmarks of ferroptosis that are implicated in AD pathology (20)

Think inflammation drivers

It is commonly studied in experimental models focused on peptide signaling, molecular interaction, and pathway activity

Future prospective studies are needed to confirm these associations and clarify underlying mechanisms

Some patients present primarily with descent of facial tissues, while others primarily have true volume loss, or deflation, he said, emphasizing that an accurate diagnosis of the balance between these two factors is essential for tailoring effective treatment plans

"The Use of Dual-Energy X-ray Absorptiometry in Obesity." Current Opinion in Endocrinology, Diabetes, and Obesity, 2018