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DeCaria JE, Sharp C, Petrella RJ

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In ECs, Ca ++ flux in response to either shear stress or a PIEZO1 agonist, Yoda, leads to cellular ATP release, followed by NO synthesis downstream of the actions of the exported ATP on purinergic receptors and endothelial NO synthase activation secondary to phosphorylation of eNOS by AKT (Wang et al., 2016)

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Side effects can be dose-dependent, which means that as the dosage is increased, your body works to adjust to the stronger impact on delayed gastric emptying and how your gut moves

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