Stat Med
1 Introduction Obesity (BMI 30 kg/m 2 ) and overweight (BMI 27 kg/m 2 ), characterized as chronic diseases and major public health issues (Ng et al., 2014
Familial multiple angiolipomatosis
Extending the findings from the UK cohort study, additional real-world data derived from the Taiwan National Health Insurance Databasewhich encompasses Asian populations characterized by lower gallstone prevalence, low-fat and high-fiber dietary patterns, and lower body mass indexalso documented an elevated risk of biliary-related diseases linked to GLP-1 RAs compared with SGLT-2 inhibitors [36]

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The development of novel formulationssuch as oral, transdermal, or alternative delivery systemsrequires sensitive and reliable quantification methods to support formulation optimization and bioavailability studies