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According to Innerbody's 2026 review, a 2013 in vitro study found treated cells showed statistically significant increases in melatonin biomarkers, and a 2021 human trial of 75 women found 0.5mg daily increased melatonin by 160% versus placebo

Concomitantly, sulforaphane significantly reduced the nuclear translocation of the pro-inflammatory transcription factor nuclear factor (NF)-B in pancreatic acinar cells, downregulating the expression of NF-B target genes that code for pro-inflammatory mediators, such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), and IL-6 ( Figure 3 ) (18)

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