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Dengue and Severe Dengue DENV is a mosquito-borne flavivirus with four distinct serotypes (DENV-1, DENV-2, DENV-3, and DENV-4), capable of causing a wide range of clinical manifestations, from mild dengue fever (DF) to severe dengue (also known as dengue hemorrhagic fever, DHF), as defined by the 2009 World Health Organization classification [41,98,99,100,101,102,103]

CONTRAINDICATIONS Sensitivity to cobalt and/or vitamin B 12 is a contraindication

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