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The mechanism proceeds through four documented steps: Folate cycle disruption MOTS-c inhibits the folate-methionine cycle, specifically targeting de novo purine biosynthesis

D-limonene suppresses doxorubicin-induced oxidative stress and inflammation via repression of COX-2, iNOS, and NFB in kidneys of Wistar rats

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For fertility induction, gonadotropin-therapy reviews (Boeri 2021) describe HCG-based regimens often combined with FSH inducing spermatogenesis in roughly 80% of hypogonadotropic men over 12-24 months

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