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In addition, ZIP8-knockout mice display impaired iron recycling during inflammation, elevated splenic iron and reduced serum iron, highlighting ZIP8s role in systemic metal handling 175

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Researchers have found that treatment with high doses of caffeine (50 mg/kg/day) for 2 weeks eased liver fibrosis, alleviated intrahepatic angiogenesis, and reduced portal pressure in rats with BDL-induced cirrhosis without adversely affecting systemic hemodynamics, supporting the benefit of using caffeine treatment in patients with cirrhosis (Chang et al., 2019)

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Peptide therapies should always be prescribed and monitored by a qualified medical provider