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Mol Pharmacol : Epub ahead of print

Of these trials, four compared DPP-4 inhibitors against placebo (SAVOR-TIMI 53, EXAMINE, TECOS, CARMELINA), eight compared GLP-1RA against placebo (ELIXA, LEADER, SUSTAIN-6, EXSCEL, HARMONY, REWIND, PIONEER 6, AMPLITUTE-O) and eleven compared SGLT-2 inhibitors against placebo (EMPA-REG, CANVAS, DECLARE, CREDENCE, DAPA-HF, DAPA CKD, VERTIS-CV, EMPEROR-R, SCORED, SOLOIST-WHF, EMPEROR-P)

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Moreover, interaction tests indicated that the associations between vitamin B2 intake and osteoporosis was modified by the variable of total MET, with the risk for OP reduced more pronounced in the subgroup of insufficiently active individuals as the increment of vitamin B2 intake (P interaction = 0.0364, Table 5)

Further in vivo studies indicated that P