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The results are "historically unprecedented with treatments other than bariatric surgery," Aaron Kelly, a study lead and the co-director of the Center for Pediatric Obesity Medicine at the University of Minnesota said at a press conference about the findings, per The Guardian

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Alternative diabetes treatments include other GLP-1 agonists (if no cross-reactivity), SGLT2 inhibitors, DPP-4 inhibitors, or insulin therapy per NICE NG28 guidance

Immune checkpoint inhibitors (ICIs), such as pembrolizumab, are newer large-molecule therapeutics that are generally presumed to spare the ovarian reserve

Pharma must therefore balance short-term commercial gains with long-term pricing sustainability across both channels and geographies

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