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Resynthesis of the essential amino acid methionine in the body is mediated by Vitamin B12

Requires medical supervision for proper dosing and side effect management

However, the current activity of LaccID is still much lower than that of APEX2 or TurboID, requiring 12 h of labeling to give detectable signal, in contrast to APEX2 or TurboID, which need only 110 min

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Sugar and fat free and suitable for low-calorie diets

Mice were put into the open field actimeter system after a 5-hour fast and locomotion metrics were recorded by the BIOSEB system for 20 minutes