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PMID 8615839

Intracellular metal ions released from internalized metal-based NPs can depolarize the mitochondrial membrane and disturbance of electron-transport chain, eventually leading to mitochondrial dysfunction (Fu et al., 2014

[1] The experimental design of that early work is itself instructive for the systemic question

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Metabolic dysregulation : When NAD+ drops, glucose metabolism and insulin sensitivity suffer