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In contrast to the AR, the structural basis of antagonism has been elucidated for other nuclear receptors, eg , from the structures of 4-hydroxyltamoxifen (4-OHT) bound to the ER 91 , RU-486 bound to the GR 91,92 and the antagonist GW6471 bound to PPAR- 93

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All reagents in this work were of analytical grade

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