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Occur in 3050% of subjects during dose titration

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The classic signs of acute inflammation are redness, heat, swelling, pain, and loss of function

Neuropsychiatric effects have been reported in post-marketing surveillance of GLP-1 receptor agonists, though the incidence and causal relationship remain unclear

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And critically, it acts on the hypothalamus to reduce appetite, creating powerful satiety signals that make people eat significantly less without feeling deprived