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Clinically validated biomarkers of OS, such as F2-isoprostanes (which indicate lipid peroxidation), 8-OHdG (which indicates DNA damage), and the activities of redox enzymes like superoxide dismutase (SOD) and glutathione peroxidase (GPx), show strong correlations with disease progression and end-organ complications

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Using semaglutide without medical necessity and supervision may lead to unnecessary risks

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Most patients report that they see or feel different in the first 8 weeks of starting semaglutide with some saying they can even see a difference after 4 weeks of use

Note that semaglutide and tirzepatide typically have different standard dosing levels, which is handled in the regression model by the drugType:dose interaction term