Keywords , weight loss , liver fibrosis , phase 3 clinical trial , metabolic syndrome , non-invasive tests 0 1 INTRODUCTION Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a leading cause of chronic liver disease worldwide, tightly linked to obesity, type 2 diabetes mellitus (T2DM), and other components of the metabolic syndrome [1]
However, only a minority of these reactions depend on immunological mechanisms (i.e., allergy) (Bjrksten & Kjellman, 1987)
[1] While some fatty acids can, long chain fatty acids cannot pass through the mitochondrial membrane
Science 338 , 11771183 (2012)
Liver Conditions: Used in alcohol-related liver disease, liver cirrhosis, and liver damage linked to HIV or hepatitis C
Underlying conditions such as hypothyroidism, Cushing's syndrome, PCOS, or obstructive sleep apnoea can blunt weight loss responses and should be investigated if not already excluded