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With retatrutide, the clinical significance of this absorption difference has not been specifically studied, but experienced researchers note that thigh injections tend to produce a slightly more gradual onset of appetite suppression compared to abdominal injections

Anything below 0.25mg has not been studied in rigorous trials for weight management outcomes

Other evidence suggests the L-cells located in the proximal jejunum are sufficient to account for the early-phase secretion through direct contact with luminal nutrients

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