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Age-related hormone changes affect both sexes and may require specific interventions beyond weight loss medication alone

Tirzepatide (Zepbound), a dual GLP-1/GIP receptor agonist, represents a newer agent with robust weight loss efficacy

The side effect pattern repeats with a few days of increased nausea after the first 1.7 mg injection, then gradual improvement

Therefore, patient education becomes central to treatment success

TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells

5 This pattern has been observed across different dieting approaches, from high-protein to low-carb, and is not limited to one specific method of weight loss