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Comprehensive analysis of gut microbial community structural characteristics, metabolite characteristic profiles, and clinical phenotype information promises discovery of critical pathogenic pathways and potential intervention targets (163) Targeted metabolic pathway intervention trials: randomized controlled clinical studies directed at specific metabolic pathways should be designed

The loading dose regimen achieved the quickest and highest increase, reaching a median vitamin B12 concentration of 1090 pmol/L (reference range 350-650 pmol/L) after 14 days

Discontinuing GLP-1 receptor agonist therapy leads to predictable physiological changes as drug levels decline and the pharmacological effects diminish

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This rapid skeletal muscle tissue damage and intramuscular infiltration of immune cells contribute to PEM-related symptoms

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