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36 The superior antagonist activity of the Gly4( S,S )-ACPC derivative relative to exendin-(9-39) suggests that the N-terminus of the ( S,S )-ACPC-containing peptide engages the TMD in a manner that is energetically favorable but ineffective for GLP-1R activation

Crimmins EM, Saito Y, Kim JK, Zhang Y, Sasson I, Hayward MD

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