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Hydration helps counteract the dehydration caused by semaglutides gastrointestinal effects

Cannabis, especially when smoked, can worsen the symptoms, leading to increased irritation and discomfort

This is partly why retatrutide produces dramatically higher weight loss than pure GLP-1 medications it drives calorie burning through glucagon's thermogenic effects, not just appetite suppression

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An HbA1c target of less than 7.0% was attained by up to 80% with high-dose GLP-1 receptor agonists and up to 97% with tirzepatide (GLP-1/GIP receptor agonist), with even up to 62% of people with T2D reaching an HbA1c of less than 5.7%