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Progression risk: NAFLD can progress to NASH (with inflammation), fibrosis, cirrhosis, and liver failure

Yet real-world observational studies have produced conflicting findings

Synuclein- one study: skin biopsy detection of phosphorylated - synuclein for diagnosis of synucleinopathies

ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS

More severe side effects such as gastroparesis had also been fairly well documented before the FDA's recent warning update to Wegovy

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