doi:10.1161/STROKEAHA.107.504498
How much of the administered dose actually reaches systemic circulation to inhibit NNMT
Track sleep duration and subjective quality to identify any changes
It means the harms are often delayed, attributed to other causes, or simply not reported

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Reported side effects are generally mild and include temporary gastrointestinal discomfort, headaches during initial use, occasional fatigue as the body adjusts, and rare nausea, especially when taken without food