indeed, its depletion has been associated with increased gut permeability [72]
This hormone plays a key role in regulating blood sugar and appetite
STEER was a retrospective, observational real-world study, evaluating the efficacy of Wegovy (semaglutide) 2.4 mg versus tirzepatide in lowering the risk of MACE in US adults with overweight or obesity and established CVD with no prior history of diabetes, with a primary outcome measure of revised 5-point MACE (heart attack, stroke, hospitalization for heart failure, coronary revascularization, and death from any cause) and revised 3-point MACE (heart attack, stroke and death from any cause)
Those seeking evidence-based approaches should explore GLP-1 clinical trial evidence for pharmaceutical options
Tsiami AP, Goulis DG, Sotiriadis AI, Kolibianakis EM
While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful
