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The trial product estimand evaluated the treatment effect while on treatment and without the use of rescue medication [60], providing a more direct evaluation of medication efficacy

For sleep support, take 200-400 mg about 1-2 hours before bedtime

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[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Jastroch M., Divakaruni A.S., Mookerjee S., Treberg J.R., Brand M.D

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in 2031, but Novo Nordisk also has several secondary patents which may extend protection through 2033 or beyond