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DMH GLP-1R neurons drive pre-ingestive, cognitive satiation via feed-forward control

Class effects, which are directly related to the mechanism of action, are common to all DPP4i

Retatrutide administered once weekly subcutaneously for 12 weeks resulted in a dose-dependent placebo-adjusted weight loss of up to 8.96 kg in the highest dose group and a placebo-adjusted HbA1c reduction of up to 1.6% in a phase II trial in individuals with T2DM [125]

Semaglutide offers more safety data and an oral option

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Additionally, research is ongoing to determine whether these drugs can also be used to treat drug addictions, Alzheimers, and Parkinsons diseases (Beckwith, 2023)