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Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioid analgesics alone

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Int J Mol Sci.2022;23:11989

increases decorin, angiogenesis, and nerve outgrowth

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DSIP was isolated by Schoenenberger and Monnier, who reported recovering it from the cerebral venous blood of rabbits during electrically induced sleep and published the characterisation in 1977