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While the science is still evolving, theres real mechanistic interest around tight junction modulators and gutprotective peptides

No tolerance developed to this protective effect, which appeared to be mediated by (1) the activation of 5-HT 1A receptors, as it was antagonized by the administration of WAY100635 30 min before stress exposure

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The cardiovascular safety demonstrated by tirzepatide in this analysis and SURPASS-4 paved the way for a large-scale cardiovascular outcomes trial