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Restarting the medication helped restore some protection, but only partially, showing that discontinuation leaves a lasting scar.

In advanced atherosclerosis stages, prostaglandin endoperoxide synthase 2 (PTGS2), ACSL4, caspase-1, and NOD-like receptor protein 3 (NLRP3) expression is upregulated, while GPX4 is downregulated

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Frequent weight fluctuations can lead to long-term metabolic and hormonal changes, making future weight loss efforts even more challenging

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