During Phase 1 detoxification, a family of enzymes known as Cytochrome P450 (CYP450) modifies toxins through oxidation
Consequently, targeting these transcription factors represents a promising strategy to eradicate CSCs, inhibit tumor growth, and overcome therapeutic resistance, offering a potential pathway for more effective cancer treatments
Davis thanked the writers and directors of her show, How to Get Away With Murder for creating her character, law professor Annalise Keating, and for thinking that a sexualized, messy, mysterious woman could be a 49-year-old, dark-skinned African-American woman who looks like me.
10.1016/j.cmet.2006.07.006 Cell Metab
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hence, FGFs induce MDR by extracellularly impacting cell regulation [70, 71]