To bypass the skin barrier, several support techniques are being studied, such as: Microneedles: Tiny needles create microchannels in the skin, allowing drugs to enter the bloodstream directly
Cleaning your tongue, not just your teeth, can help too
Combination Approaches Future treatments might combine incretin agonists with other weight loss mechanisms like metabolism boosters, appetite suppressants working through non-incretin pathways, or fat absorption inhibitors
Topiramate is an anticonvulsant that works by enhancing GABA activity in the brain, while GLP-1 medications like semaglutide directly bind to GLP-1 receptors to control appetite and blood sugar
They are commonly prescribed off-label for weight loss
However, continuous research and vigilant monitoring are essential to optimize their safe use [55] [56], particularly as these medications are used in broader populations for longer durations