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B12 is water-soluble, so excess amounts are usually excreted in urine

However, exclusive use of folic acid in treating vitamin B12 deficient megaloblastic anemia could result in progressive and irreversible neurologic damage

Immunoassay cross-reactivity varies

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Together, these effects contribute to hypertension ( GA also exerts several effects on the endocrine and reproductive systems

As in the open label study [27], weight gain was not uniform across the population