When physicians initiate insulin therapy, either basal insulin or premixed insulin [1718], they should understand the pharmacodynamic profile of each formulation and also consider the baseline HbA1c in conjunction with submaximal doses of sulfonylurea (SU), blood glucose levels in a fasting or postprandial state, and symptoms of hyperglycemia (polyuria or polydipsia)
HPLC and HPLC-MS/MS HPLC analysis was performed using two Shimadzu LC-10AT VP pumps gradient-controlled HPLC system, equipped with photodiode array detector (SPD-10AVP), attached with Shimadzu LC Solution program
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