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Alves FD, Lane TPM, Nguyen AI, Bush S, Ayton

Targeting JAK/STAT signaling pathway in inflammatory diseases

doi: 10.1016/j.ejmech.2019.111770 84

GLP-1 and muscle mass preservation for women Women naturally have less muscle mass than men and can lose muscle more easily during weight loss

In summary, incretin receptor agonists demonstrate consistent anti-fibrotic effects in vivo , reducing hepatic stellate cell activation, oxidative stress, and collagen deposition in animal models, and improving fibrosis outcomes in clinical MASLD and MASH studies

It should be noted that the sequestration process in the macro-and micro-types can be either non-selective, which primarily occurs during nutrient starvation, or selective when targeting specific cargoes towards autophagosomes