In mouse models, dual agonism had superior efficacy for weight loss and glucose control compared to a GLP-1RA alone 9 , with additive effects of the GIPR proposed to act through signaling in beta cells 10 , alpha cells 11 , the CNS (central nervous system) 12,13 and adipocytes 14
Among the studys most notable findings: The pace of biological aging slowed by 9% according to the DunedinPACE epigenetic clock
doi: 10.1016/j.appet.2006.10.008 9 UdoTGriloCMMcKeeSA
Nervous System Regulate autonomic nervous system and treat inflammation of nerves
Enzyme-inducing AEDs like carbamazepine and phenytoin can reduce vitamin D levels, and many commonly used AEDs have been shown to lower folate and vitamin B12
Notably, weight loss appeared to be exposure-dependent, with the cohort receiving the maximum dose of 2 mg/day for the entire study exhibiting the greatest weight loss ( Table 2 )