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It is caused by the accumulation of misfolded or unfolded proteins in the ER lumen, resulting in overexpression of ER stress markers such as growth arrest and DNA damage-inducible protein 153 (CCAAT/enhancer binding protein homologous protein), glucose-regulated protein 78 (GRP78), and C/-EBP homologous protein (CHOP)

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In clinical trials studying the FDA-approved formulation, participants experienced meaningful average weight-loss outcomes when the medication was combined with reduced-calorie diets and increased physical activity

How do GLP-1 analogs confer health benefits