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At up to 80 weeks, the results were comparable to bariatric surgery outcomes, which is remarkable for a medication-based intervention
Do not use retatrutide if you have: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis Severe gastroparesis or other serious GI motility disorders Known hypersensitivity to any component of the drug Use with caution and close monitoring if you have: Existing cardiovascular disease, given the heart rate increase Gallbladder disease or a history of gallstones Kidney disease, as dehydration from GI side effects can worsen kidney function Type 1 diabetes or insulin-dependent Type 2 diabetes A history of eating disorders, as extreme appetite suppression can interact with disordered eating patterns in unpredictable ways Pregnancy is an absolute contraindication
GLP-1RA/tesaglitazar does not differ from the pharmacokinetically matched GLP-1RA in GLP-1R signalling, but shows GLP-1R-dependent PPAR-retinoic acid receptor heterodimerization and enhanced improvements of body weight, food intake and glucose metabolism relative to the GLP-1RA or tesaglitazar alone in obese male mice
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