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The metabolism of catalpol in rats is mainly mediated by the intestinal microbiota, resulting in the formation of an aglycone-containing hemiacetal hydroxyl structure ( in vivo ( FIGURE 8 At present, the research field of catalpol has developed from the initial extraction and determination of active ingredients to the mechanism research of basic experiments, and then to the clinical research and new drug development in recent years, showing the transformation process from traditional Chinese medicine monomer to clinical application

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Ipamorelin is a synthetic pentapeptide (5 amino acids) growth hormone secretagogue developed by Novo Nordisk in the late 1990s

In experimental models, researchers may explore processes such as receptor-mediated signaling, pulsatile hormone release dynamics, and downstream metabolic pathway modulation

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