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Does DSIP have other studied biological properties
19 Under oxidative stress, the glutathione (GSH) level in cardiomyocytes decreases by 6070%, and the levels of Gln, glutamate and -ketoglutarate (-KG) also decrease significantly, while the enzyme activity of GLS, which converts Gln to glutamate, is enhanced
doi: 10.3390/biology9060126 141 GiraudASMenheniottTRJuddLM
Consistent with the importance of glutamine in stressful situations, glutamine deprivation induces cellular stress
Curcumin can activate Nrf2 signaling pathway via inhibiting Keap1, upregulating Nrf2 and inducing the nuclear translocation of Nrf2 ( via Sirtuin-1-Nrf2-ARE signaling pathway (Liu et al., 2022c)
