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A 2026 network meta-analysis by Bernardi and colleagues pooled 28 randomized trials and over 34,000 patients and confirmed tirzepatides superiority for weight reduction, BMI, waist circumference, A1c, and fasting glucose.[5] The data is consistent

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The use of healthy subjects is in line with regulatory recommendations for DDI studies [17, 18] and is consistent with other DDI trials [12, 19]