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Although these enolases have been shown to facilitate this process both in vivo and in vitro , it would appear as though the plasmin activity facilitated by all three of the major human schistosomes does not rely solely on enolases, as up to 10 plasminogen binding proteins have been identified via western blotting techniques

In the nucleus, following heterodimer complex formation with transcription factors, like small Maf proteins (G/F/K) and c-Jun, Nrf2 complexes bind to the antioxidant response element (ARE), a regulatory enhancer region within gene promoters that upregulate antioxidant and anti-inflammatory defense processes (Cuadrado et al., 2019

[DOI] [PubMed] [Google Scholar] 122.Gouaze V, Andrieu-Abadie N, Cuvillier O, Malagarie-Cazenave S, Frisach MF, Mirault ME, Levade T